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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
Hispidin Chemical Structure
 BCP34507 Hispidin 555-55-5
Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.
TC-S 7001 Chemical Structure
 BCP34134 TC-S 7001 867017-68-3
TC-S 7001 is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1?nM for human ROCK-1 and ROCK-2, respectively.
Y-27632 Dihydrochloride Hydrate Chemical Structure
 BCP26044 Y-27632 Dihydrochloride Hydrate 331752-47-7
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively, which primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
LDN-212854 Chemical Structure
 BCP14671 LDN-212854 143259726-6
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2.
VTX-27 Chemical Structure
 BCP32667 VTX-27 1321924-70-2
VTX-27 is a novel potent and selective PKCθ inhibitor.
4alpha-PDD Chemical Structure
 BCP32104 4alpha-PDD 27536-56-7
4alpha-PDD is a negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA). Though it is inactive for signaling through PKC, 4alpha-PDD has been shown to activate transient receptor potential vanilloid 4 (TRPV4) channels.
CCG-222740 Chemical Structure
 BCP31985 CCG-222740 1922098-69-8
CCG-222740 is a potent and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 also is a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.
Ripasudil Hydrochloride Chemical Structure
 BCP24238 Ripasudil Hydrochloride 223644-02-8
Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively.
GSK269962 Chemical Structure
 BCP27824 GSK269962 850664-21-0
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK269962 can become an alternative worth considering in OAB treatment.
Glycyl-H 1152 dihydrochloride Chemical Structure
 BCP27782 Glycyl-H 1152 dihydrochloride 913844-45-8
Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride with an improved selectivity for ROCKII (IC50 = 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC, respectively).
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