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Potassium Channel

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Potassium Channel

Chemical Structure Cat. No. Product Name CAS No.
Procainamide Chemical Structure
 BCP35189 Procainamide 51-06-9
Procainamide is an oral antiarrhythmic agent that has been in use for more than 60 years. Long term procainamide therapy is known to induce hypersensitivity reactions, autoantibody formation and a lupus-like syndrome but is a rare cause of clinically apparent acute liver injury.
Amiodarone Chemical Structure
 BCP35085 Amiodarone 1951-25-3
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
XE 991 dihydrochloride Chemical Structure
 BCP34697 XE 991 dihydrochloride 122955-13-9
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.
ML402 Chemical Structure
 BCP34009 ML402 298684-44-3
ML402 is a selective TREK-1 activator.
MCHr1 antagonist 2 Chemical Structure
 BCP33948 MCHr1 antagonist 2 863115-70-2
MCH-R1 antagonist 22 is a novel potent antagonist of melanin concentrating hormone receptor 1 (MCH-R1).
Sematilide hydrochloride Chemical Structure
 BCP25510 Sematilide hydrochloride 101526-62-9
Sematilide hydrochloride is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.
VU0134992 Chemical Structure
 BCP33228 VU0134992 755002-90-5
VU0134992 is a selective Kir4.1 potassium channel pore blocker.
VU 590 dihydrochloride Chemical Structure
 BCP33112 VU 590 dihydrochloride 313505-85-0
VU 590 dihydrochloride inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM).
QO-40 Chemical Structure
 BCP33055 QO-40 1259536-70-3
QO-40 is an activator of KCNQ2/3 potassium channels.
KB-130015 Chemical Structure
 BCP33047 KB-130015 147030-48-6
KB-130015 is a novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages.
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