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PKC

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PKC

Chemical Structure Cat. No. Product Name CAS No.
Hispidin Chemical Structure
 BCP34507 Hispidin 555-55-5
Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.
VTX-27 Chemical Structure
 BCP32667 VTX-27 1321924-70-2
VTX-27 is a novel potent and selective PKCθ inhibitor.
4alpha-PDD Chemical Structure
 BCP32104 4alpha-PDD 27536-56-7
4alpha-PDD is a negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA). Though it is inactive for signaling through PKC, 4alpha-PDD has been shown to activate transient receptor potential vanilloid 4 (TRPV4) channels.
Bisindoylmaleimide X Chemical Structure
 BCP25395 Bisindoylmaleimide X 1241725-89-2
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
LXS-196 2HCl Chemical Structure
 BCP30427 LXS-196 2HCl LXS-196HCl
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
MDK-8650 Chemical Structure
 BCP30378 MDK-8650 736048-65-0
MDK-8650 is a selective PKC-θinhibitor, with an IC50 of 12 nM.
PKC-IN-1 Chemical Structure
 BCP10410 PKC-IN-1 1046787-18-1
PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies.
TX-1918 Chemical Structure
 BCP16358 TX-1918 503473-32-3
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
UCN-01 Chemical Structure
 BCP14345 UCN-01 112953-11-4
UCN-01 (7-hydroxystaurosporine) acts as an inhibitor against many phosphokinases, such as the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases.
UCN-02 Chemical Structure
 BCP14344 UCN-02 121569-61-7
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