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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
BDTX-189 Chemical Structure
BCP37532 BDTX-189 2414572-47-5
BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
CH7233163 Chemical Structure
BCP37295 CH7233163 CH7233163
CH7233163 overcomes osimertinib resistant EGFR-Del19/T790M/C797S mutation
Deuruxolitinib Chemical Structure
BCP36774 Deuruxolitinib 1513883-39-0
Pyrotinib Racemate Chemical Structure
BCP36485 Pyrotinib Racemate 1246089-97-3
Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
AZD-4205 Chemical Structure
BCP36112 AZD-4205 2091134-68-6
AZD4205 is a novel potent and selective janus kinase 1 (JAK1) inhibitor.
TAS6417 HCl Chemical Structure
BCP35916 TAS6417 HCl TAS6417HCl
TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.
Gusacitinib hydrochloride Chemical Structure
BCP35707 Gusacitinib hydrochloride 2228989-14-6
Gusacitinib (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.
TG-89 Chemical Structure
BCP35054 TG-89 936091-56-4
TG-89 is an inhibitor of JAK2, FLT3, RET and JAK3.
AG556 Chemical Structure
BCP35023 AG556 133550-41-1
AG-556 is an epidermal growth factor receptor (EGFR) kinase inhibitor.
Delgocitinib Chemical Structure
BCP34832 Delgocitinib 1263774-59-9
Delgocitinib is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
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