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Chemical Structure Cat. No. Product Name CAS No.
MKC3946 Chemical Structure
BCP20799 MKC3946 1093119-54-0
MKC3946 is a potent and soluble IRE1α inhibitor. MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells.
KIRA6 Chemical Structure
BCP26100 KIRA6 1589527-65-0
KIRA6 allosterically inhibits IRE1α RNase kinase activity with an IC50 of 0.6 μM.
APY29 Chemical Structure
BCP09071 APY29 1216665-49-4
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
STF 083010 Chemical Structure
BCP16458 STF 083010 307543-71-1
STF-083010 is a novel small-molecule inhibitor of Ire1α; inhibits Ire1 endonuclease activity, without affecting its kinase activity after endoplasmic reticulum stress both in vitro and in vivo.
4μ8C Chemical Structure
BCP21011 4μ8C 14003-96-4
4μ8C is selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
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