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HSP

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HSP

Chemical Structure Cat. No. Product Name CAS No.
Retaspimycin hydrochloride Chemical Structure
 BCP36508 Retaspimycin hydrochloride 857402-63-2
Retaspimycin Hydrochloride is a potent and water-soluble inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9.
Tamoxifen Chemical Structure
 BCP33248 Tamoxifen 10540-29-1
Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen activates autophagy and induces apoptosis.
JG98 Chemical Structure
 BCP31061 JG98 1456551-16-8
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
Alvespimycin HCl Chemical Structure
 BCP22705 Alvespimycin HCl 467214-21-7
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
Debio 0932 Chemical Structure
 BCP27980 Debio 0932 1061318-81-7
Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.
TRC 051384 Chemical Structure
 BCP29281 TRC 051384 867164-40-7
TRC051384 is a heat shock protein 70 (HSP70) inducer.
TAS-116 Chemical Structure
 BCP25132 TAS-116 1260533-36-5
TAS-116 is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity.
3-Methyltoxoflavin Chemical Structure
 BCP30844 3-Methyltoxoflavin 32502-62-8
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM.
MKT-077 Chemical Structure
 BCP30211 MKT-077 147366-41-4
MKT-077 is an inhibitor of mitochondrial hsp70 family member mortalin (mot-2), causing the selective death of cancer cells.
KNK437 Chemical Structure
 BCP28527 KNK437 218924-25-5
KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.
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