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Chemical Structure Cat. No. Product Name CAS No.
Mobocertinib succinate Chemical Structure
BCP33315 Mobocertinib succinate 2389149-74-8
Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.
Mobocertinib Chemical Structure
BCP31045 Mobocertinib 1847461-43-1
Mobocertinib (TAK-788,AP32788) is a small, oral inhibitor of EGFR [epidermal growth factor receptor] and HER2 [human epidermal growth factor receptor 2].
AZD-8931 Difumaric acid Chemical Structure
BCP24789 AZD-8931 Difumaric acid 1196531-39-1
AZD-8931 is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.
AV-412 Tosylate Chemical Structure
BCP23783 AV-412 Tosylate 451493-31-5
AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
Pyrotinib Chemical Structure
BCP29458 Pyrotinib 1269662-73-8
Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively.
Pyrotinib maleate Chemical Structure
BCP29462 Pyrotinib maleate 1397922-61-0
Pyrotinib also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity.
Epertinib Chemical Structure
BCP29362 Epertinib 908305-13-5
Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively; Epertinib shows potent antitumor activity.
Tyrphostin AG 879 Chemical Structure
BCP08354 Tyrphostin AG 879 148741-30-4
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA.
BMS-599626 HCl Chemical Structure
BCP01780 BMS-599626 HCl 873837-23-1
BMS-599626 (AC480) is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.
BMS-599626 Chemical Structure
BCP19580 BMS-599626 714971-09-2
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc.
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