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GPCR/G Protein
Guanylate Cyclase

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Guanylate Cyclase

Chemical Structure Cat. No. Product Name CAS No.
Nelociguat Chemical Structure
BCP16721 Nelociguat 625115-52-8
Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.
ODQ Chemical Structure
BCP06748 ODQ 41443-28-1
ODQ potent and selective inhibitor of soluble guanylyl cyclase (sGC). The binding of ODQ is competitive with NO.
MGV354 Chemical Structure
BCP30642 MGV354 1852495-86-3
MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma.
Plecanatide Chemical Structure
BCP25087 Plecanatide 467426-54-6
Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.
Vericiguat Chemical Structure
BCP18886 Vericiguat 1350653-20-1
Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
BAY 41-2272 Chemical Structure
BCP16012 BAY 41-2272 256376-24-6
BAY 41-2272 is a soluble guanylate cyclases (sGC) activator.
Cinaciguat Chemical Structure
BCP07942 Cinaciguat 329773-35-5
Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure.
Cinaciguat hydrochloride Chemical Structure
BCP30226 Cinaciguat hydrochloride 646995-35-9
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
Lificiguat Chemical Structure
BCP09072 Lificiguat 170632-47-0
YC-1(Lificiguat) is a soluble guanylyl cyclase(sGC) activator; binds to the heme-containing domain of the β subunit with Kd value of 0.6-1.1 μM in the presence of CO.
Riociguat Chemical Structure
BCP04750 Riociguat 625115-55-1
Riociguat is a novel drug that is currently in clinical development by Bayer.
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