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Gamma secretase

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Gamma secretase

Chemical Structure Cat. No. Product Name CAS No.
CHF 5074 Chemical Structure
BCP30410 CHF 5074 749269-83-8
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
PF-03084014 Chemical Structure
BCP28117 PF-03084014 865773-15-5
PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
LY900009 Chemical Structure
BCP27986 LY900009 209984-68-9
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
BMS299897 Chemical Structure
BCP06241 BMS299897 290315-45-6
BMS-299897 markedly reduced both brain and plasma Abeta in APP-YAC mice with ED(50) values of 86 and 22 mg/kg per os (po), respectively.
Gamma-Secretase Modulators Chemical Structure
BCP12943 Gamma-Secretase Modulators 937812-80-1
Gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. Gamma-Secretase Modulators is useful for Alzheimer's disease.
NGP-555 Chemical Structure
BCP25746 NGP-555 1304630-27-0
NGP555 is a γ-secretase modulator.
L685458 Chemical Structure
BCP16163 L685458 292632-98-5
L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
γ-Secretase Inhibitor XXI Chemical Structure
BCP02178 γ-Secretase Inhibitor XXI 209986-17-4
γ-Secretase Inhibitor XXI, Compound E is a cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC50 = 300 pM for Aβ40 in CHO cells overexpressing wild type βAPP.
RO4929097 Chemical Structure
BCP02623 RO4929097 847925-91-1
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
MK-0752 Chemical Structure
BCP05305 MK-0752 471905-41-6
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.
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