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GABA Receptor

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GABA Receptor

Chemical Structure Cat. No. Product Name CAS No.
Clomethiazole Chemical Structure
 BCP36337 Clomethiazole 533-45-9
Chlormethiazole is an potent and orally active GABAA agonist. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus.
Golexanolone Chemical Structure
 BCP36048 Golexanolone 2089238-18-4
Golexanolone is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC.
4-Aminobutyric acid Chemical Structure
 BCP34675 4-Aminobutyric acid 56-12-2
Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission.
Loreclezole Chemical Structure
 BCP33207 Loreclezole 117857-45-1
Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
Gabazine Chemical Structure
 BCP33110 Gabazine 105538-73-6
Gabazine is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.
Tracazolate Chemical Structure
 BCP33109 Tracazolate 41094-88-6
Tracazolate is a GABAA receptor modulator.
SJM-3 Chemical Structure
 BCP33082 SJM-3 1234977-97-9
SJM-3 is a Positive Allosteric Modulator of GABA(A) Receptors.
AA 29504 Chemical Structure
 BCP33080 AA 29504 945828-50-2
AA 29504 is a positive allosteric modulator of GABAA receptors.
CGS 20625 Chemical Structure
 BCP33079 CGS 20625 111205-55-1
CGS 20625 is a partial agonist for the benzodiazepine binding site of the GABAA receptor used as an anti-anxiety drug. It acts as a central benzodiazepine receptor agonist (IC50 = 1.3 nM) with no affinity for other neurotransmitter receptor binding sites.
TP-003 Chemical Structure
 BCP26045 TP-003 628690-75-5
TP003 is a functionally selective GABAA receptor (α3 subtype) partial agonist.
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