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FGFR

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FGFR

Chemical Structure Cat. No. Product Name CAS No.
Pemigatinib Chemical Structure
 BCP31812 Pemigatinib 1513857-77-6
Pemigatinib is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
Rogaratinib Chemical Structure
 BCP25142 Rogaratinib 1443530-05-9
Rogaratinib is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.
S49076 HCl Chemical Structure
 BCP35053 S49076 HCl 1265965-19-2
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.
BO-264 Chemical Structure
 BCP33848 BO-264 2408648-20-2
BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity.
Alofanib Chemical Structure
 BCP31905 Alofanib 1612888-66-0
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity.
Lucitanib hydrochloride Chemical Structure
 BCP21230 Lucitanib hydrochloride 1058137-84-0
Lucitanib is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.
Tyrosine kinase-IN-1 Chemical Structure
 BCP30849 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
ODM-203 HCl Chemical Structure
 BCP30289 ODM-203 HCl ODM-203hcl
ODM-203 is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
FGF401 Chemical Structure
 BCP25143 FGF401 1708971-55-4
FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.
ODM-203 Chemical Structure
 BCP30030 ODM-203 1430723-35-5
ODM-203 is an orally available inhibitor of the human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs), with potential antiangiogenic and antineoplastic activities.
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