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E1 E2 E3 Enzyme

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E1 E2 E3 Enzyme

Chemical Structure Cat. No. Product Name CAS No.
NAcM-OPT Chemical Structure
 BCP35044 NAcM-OPT 2089293-61-6
NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM
CC-92480 Chemical Structure
 BCP32805 CC-92480 2259648-80-9
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity.
DKM 2-93 Chemical Structure
 BCP32598 DKM 2-93 65836-72-8
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
COH000 Chemical Structure
 BCP31057 COH000 1534358-79-6
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.
Thalidomide Chemical Structure
 BCP19772 Thalidomide 50-35-1
Thalidomide is initially promoted as a sedative, inhibits ereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ～250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
TAME Chemical Structure
 BCP02395 TAME 901-47-3
Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.
CC220 Chemical Structure
 BCP20299 CC220 1323403-33-3
Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay.
Suramin sodium Chemical Structure
 BCP13783 Suramin sodium 129-46-4
Suramin sodium salt is a polysulfonated naphthylurea with various biological activities.
Tasisulam Chemical Structure
 BCP05154 Tasisulam 519055-62-0
Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway.
ML792 Chemical Structure
 BCP30807 ML792 1644342-14-2
ML-792 is a potent and selective SAE inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.
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