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CFTR

Chemical Structure Cat. No. Product Name CAS No.
Elexacaftor R enantiomer Chemical Structure
 BCP35907 Elexacaftor R enantiomer 2229860-99-3
Elexacaftor (VX-445,) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
Deutivacaftor Chemical Structure
 BCP19794 Deutivacaftor 1413431-07-8
Deutivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator potentially for the treatment of cystic fibrosis.
Elexacaftor Chemical Structure
 BCP29711 Elexacaftor 2216712-66-0
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 (compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
FDL169 Chemical Structure
 BCP30546 FDL169 1628416-28-3
FDL169 is an experimental therapy for cystic fibrosis (CF) that is being developed by Flatley Discovery Lab.
VX-659 Chemical Structure
 BCP29456 VX-659 2204245-48-5
VX-659 is a CFTR protein inhibitor.
ABBV-2222 Chemical Structure
 BCP25130 ABBV-2222 1918143-53-9
ABBV-2222, also known as GLPG2222, is a CFTR corrector being studied for the treatment of cystic fibrosis (CF).
VX-661 Chemical Structure
 BCP07173 VX-661 1152311-62-0
VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface.
KM 11060 Chemical Structure
 BCP17185 KM 11060 774549-97-2
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector.
GLPG1837 Chemical Structure
 BCP23611 GLPG1837 1654725-02-6
A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively; shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.
CFTRinh-172 Chemical Structure
 BCP15834 CFTRinh-172 307510-92-5
CFTR(inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki approximately 300 nM.
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