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Cell Cycle/DNA Damage

Chemical Structure Cat. No. Product Name CAS No.
CDKI-73 Chemical Structure
BCP37660 CDKI-73 1421693-22-2
CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM. It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.
AZ32 Chemical Structure
BCP37674 AZ32 2288709-96-4
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
Lobeglitazone Chemical Structure
BCP37672 Lobeglitazone 607723-33-1
Lobeglitazone is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity. Besides its activation of peroxisome proliferator-activated receptor (PPAR) gamma, lobeglitazone is also a potent agonist for PPARalpha.
SKLB-23bb Chemical Structure
BCP37616 SKLB-23bb 1815580-06-3
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
UBCS039 Chemical Structure
BCP37615 UBCS039 358721-70-7
UBCS039 is the first synthetic Sirt6 activator.
R-10015 Chemical Structure
BCP37585 R-10015 2097938-51-5
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
A-3 Hydrochloride Chemical Structure
BCP37347 A-3 Hydrochloride 78957-85-4
A-3 hydrochloride is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.
CX5461dihydrochloride Chemical Structure
BCP37427 CX5461dihydrochloride CX-54612HCl
CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).
SRT2183 Chemical Structure
BCP37408 SRT2183 1001908-89-9
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.
ASLAN003 Chemical Structure
BCP36999 ASLAN003 1035688-66-4
ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase).
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