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Aurora

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Aurora

Chemical Structure Cat. No. Product Name CAS No.
SP-146 Chemical Structure
BCP35921 SP-146 SP-146
SP-146 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM.
Phthalazinone pyrazole Chemical Structure
BCP33311 Phthalazinone pyrazole 880487-62-7
Phthalazinone pyrazole is a potent, selective and orally bioavailable inhibitor of Aurora-A kinase.
 Chemical Structure
Aurora Kinase Inhibitor III Chemical Structure
BCP30248 Aurora Kinase Inhibitor III 879127-16-9
Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).
Cenisertib Chemical Structure
BCP28083 Cenisertib 871357-89-0
Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer.
CCT241736 Chemical Structure
BCP29563 CCT241736 1402709-93-6
CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan? technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).
AT9283 Chemical Structure
BCP11714 AT9283 896466-04-9
AT9283 is a multi-targeted inhibitor with IC50s of 1.2 nM, 1.1 nM for JAK2 and JAK3, respectively, and is also potent to Aurora A, Aurora B and Abl(T315I).
ABT-348 Chemical Structure
BCP07256 ABT-348 1227939-82-3
ABT-348, is a novel potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials.
BI 847325 Chemical Structure
BCP15994 BI 847325 1207293-36-4
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
XL-228 Chemical Structure
BCP08143 XL-228 898280-07-4
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases.
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