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Dolutegravir Chemical Structure

Dolutegravir

Cat. No. :BCP02329CAS No. :1051375-16-6Purity:98%
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Synonyms GSK1349572;GSK 1349572;GSK-1349572;S/GSK1349572;S-349572
CAS Number 1051375-16-6
Purity 98%
M. Wt 419.38
Formula C20H19F2N3O5
Storage Store at 4-8°C
Dolutegravir is an orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication.

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